SCI epicentre: macrophages and axons


Despite great advances in the last century, there are still no satisfactory spinal cord injury (SCI) therapies that completely restore lost function. Post-SCI tissue repair is limited by factors that are neuron-intrinsic (insufficient growth response) and -extrinsic (including inflammation). Gaudet aims to develop a research program focused on modulating “endogenous combinatorial targets” to improve neuroprotection and functional recovery. Revealing novel neuron-intrinsic and -extrinsic targets for repair could help establish new therapies for SCI and other neurological conditions.



Using innovative techniques and experimental design, Gaudet aims to explore and manipulate neuron-immune cell interactions to improve spinal cord repair and behavioural recovery.

Specifically, Dr Gaudet aims to reveal novel convergent targets that benefit neuron and immune cell responses to spinal cord injury, potentially regulating key post-injury events:

• Behavioural recovery
• Axon plasticity and regeneration
• Neurotoxicity (secondary damage)
• Chronic neuroinflammation
• Glial scar deposition
• Neuropathic pain



The broad knowledge base required for studying neuroimmunology enables collaboration in other important research areas: Gaudet has studied other prevalent pathologies, including obesity and depression. Gaudet enjoys collaborating with others – whether across the hall or across the ocean – to help unravel complex processes and identify potential therapies.


Also see Publications.