Dr Gaudet aims to develop a research program focused on modulating “endogenous combinatorial targets” to improve neuroprotection and functional recovery. Revealing novel neuron-intrinsic and -extrinsic targets for repair could help establish new therapies for spinal cord injury and other neurological conditions.
OVERVIEW Despite great advances in the last century, there are still no satisfactory spinal cord injury (SCI) therapies that completely restore lost function. Post-SCI tissue repair is limited by factors that are neuron-intrinsic (insufficient growth response) and -extrinsic (including inflammation). Gaudet aims to
REFEREED PUBLICATIONS Gaudet AD, Ayala MT, Schleicher WE, Smith EJ, Bateman EM, Maier SF, Watkins LR. Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury. Experimental Neurology. 2017;295:46-54. Pubmed | .pdf Grace PM, Gaudet AD, Staikopoulos V, Maier